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“In vitro neurotoxicity screening of engine oil- and hydraulic fluid-derived aircraft cabin bleed-air contamination”
In our recent article, we present in vitro data on the neurotoxic effects and potency of possible aircraft cabin air contamination deriving from engine oils and hydraulic fluids. For this work, we exposed rat primary cortical cells cultured on micro-electrode arrays to the fumes derived from selected engine oils and hydraulic fluids and monitored changes in the spontaneous neuronal activity over 48h. Interestingly, our results indicate that fumes derived from the selected hydraulic fluids exhibits higher neurotoxic potency. Furthermore, we compare the inhibitory effects seen for the fume extracts with the effects of organophosphorus flame retardants (Triphenyl Phosphate and Tri-n-butyl Phosphate). The comparison not only suggests that the organophosphorus flame retardants contribute to the neurotoxicity of the hydraulic fluid-derived fume extracts, but also highlighted that other compounds in the fumes may contribute to the observed neurotoxic effects.
For more details see the full article (open access) here:
“In vitro neurotoxicity screening of engine oil- and hydraulic fluid-derived aircraft cabin bleed-air contamination”
