“Neuroactivity screening of botanical extracts using microelectrode array (MEA) recordings”

Our work in collaboration with the HESI Botanical Safety Consortium was recently published!

The HESI Botanical Safety Consortium collaborates to develop screening strategies to efficiently identify botanical-induced toxicity. We presented in vitro data that evaluates the applicability of multi-well microelectrode array (MEA) recordings for screening and prioritizing botanical extracts for their neuroactive potential.

Most botanical extracts tested in this study inhibit neuronal activity in vitro, although some botanicals result in extraordinary excitatory activity patterns. The results also show that MEA recordings in rat cortical cultures provide an efficient tool for screening the neurotoxicity of botanical extracts.

For more details see the full article (open access) here:

“Neuroactivity screening of botanical extracts using microelectrode array (MEA) recordings”https://doi.org/10.1016/j.fct.2024.114438