In vitro neurotoxicity of particles from diesel and biodiesel fueled engines following direct and simulated inhalation exposure

In our recent article, we present in vitro data on the neurotoxicity of combustion-derived particulate matter (PM). Specifically, we studied and compared the effects and potency of PM generated using diesel and biodiesel fuel on neuronal function. Moreover, we applied a novel approach to investigate the indirect effects of particles on neuronal function and health upon simulated inhalation exposure and thereby incorporated the systemic exposure route and secondary exposure effect. Our findings indicate that combustion-derived PM potently inhibit neuronal function following direct exposure, while the lung serves as a protective barrier. Furthermore, PM generated from regular diesel fuel exhibit a higher direct neurotoxic potency than PM from biodiesel alternative. Our study provides important toxicity data for risk assessors and regulators to evaluate the possible reduction in human health hazard by replacing petroleum-based diesel with biodiesel.

For more details see the full article (open access) here: “In vitro neurotoxicity of particles from diesel and biodiesel fueled engines following direct and simulated inhalation exposure” https://doi.org/10.1016/j.envint.2024.108481