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Comparison of the neurotoxic potency of different ultrafine particle fractions from diesel engine exhaust following direct and simulated inhalation exposure
In our recent study, we investigated the neurotoxicity of ultrafine particles (< 100 nm; UFP) emitted from diesel engines, comparing different fuel types and particle fractions. Specifically, we studied the effect of solid and semi-volatile organic compound (SVOC) UFP derived from petroleum diesel and Hydrotreated Vegetable Oil-type fuel on neuronal function after direct exposure and simulated inhalation exposure. Our data indicate that SVOC UFP are more potent in reducing neuronal activity of rat primary cortical cultures than solid UFP which only had limited effect on the neuronal function. Moreover, UFP samples collected from petroleum diesel combustion were more potent than those deriving from Hydrotreated Vegetable Oil-type fuel combustion. Taken together, our findings suggest that future policies and mitigation strategies should consider the (neuro)toxic potency of the SVOC UFP fraction and supports the transition to aromatic-free fuel alternatives in order to reduce the hazard of diesel combustion-derived UFP.
For more details see the full article (open access) here:
“Comparison of the neurotoxic potency of different ultrafine particle fractions from diesel engine exhaust following direct and simulated inhalation exposure”
