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A Review of Toxicological and Exposure Data on Polymeric Antioxidant By-products
Our latest review on antioxidant by-products (ABPs) has been published in Reviews of Environmental Contamination and Toxicology!
This work summarizes the current state of toxicological, ecotoxicological, exposure, and mechanistic data on ABPs—also known as Arvin substances, which are degradation products of antioxidants formed under heat or pressure.
Toxicological data were identified for ABP 1 (4-ethylphenol), ABP 2 (4-tert-butylphenol), ABP 4 (2,4-di-tert-butylphenol), and ABP 9 (methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate), showing systemic effects (notably in the liver and stomach) and developmental impacts in zebrafish. In contrast, limited or no toxicological and/or ecotoxicological data were available for ABP 3, 5, 6, 7, 8, and 10, and exposure data remain scarce for ABP 5, 7, 8, and 9.
We highlight the need for further research on ABPs lacking data—particularly mammalian studies focusing on liver and stomach effects, as well as zebrafish studies addressing acute, chronic, and developmental toxicity. Exposure and biomonitoring research is also essential to support a more comprehensive risk assessment of ABPs.
For more details see the full article (open access) here:
A Review of Toxicological and Exposure Data on Polymeric Antioxidant By-products