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Inhibitory effects of (synthetic) cannabinoids and (designer) benzodiazepines on spontaneously active neuronal networks of primary rat cortical cultures in vitro
The use of novel psychoactive substances (NPS), often sold as so-called “designer drugs,” has risen sharply over the past two decades and is increasingly linked to serious health incidents. In our latest study, we investigated how a range of commonly used and emerging psychoactive drugs affect neuronal activity using rat primary cortical cells cultured on micro-electrode arrays (MEA). The drugs included cannabidiol (CBD), a synthetic cannabinoid, several prescription benzodiazepines, and two designer benzodiazepines.
Our results showed that all tested substances disrupted normal brain activity. These drugs reduce neuronal activity, while also altering the timing and structure of neural bursts, with designer benzodiazepines being particularly potent compared to their prescription counterparts.
This study shows that MEA recordings can be used to rapidly screen and compare the neurotoxic potential of emerging drugs. The high potency of some designer substances is alarming and highlights the urgent need for improved monitoring, regulation, and public awareness to protect public health.
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