In collaboration with the Department of Pharmacology and Toxicology (Maastricht University) and the Office for Risk Assessment and Research (Netherlands Food and Consumer Product Safety Authority) we investigated the interaction of Tetrodotoxin (TTX) with pharmaceutical drugs known to also inhibit voltage-gated sodium (NaV) channels. We provide concentration-effect curves for inhibition of neuronal activity by TTX…

Join us in congratulating Axion Travel Award recipient Emma Kasteel!​ We are pleased to offer this award to support the important work being done by Emma and her team at the Institute for Risk Assessment Sciences at Utrecht University. Their study utilizing mice and rat primary cortical cultures showed that some types, sizes, and shapes of micro and…

Het EU-verbod op microplastics in make-up laat nog jaren op zich wachten. Maar studies wijzen op het gevaar van de deeltjes, zegt toxicoloog Emma Kasteel. “De eerste aanwijzing is dat ze ontstekingen veroorzaken en effect hebben op de hormoonhuishouding.”

We are happy to announce that our paper, titled ‘Organophosphate insecticides disturb neuronal network development and function via non-AChE mediated mechanisms’ has been published in NeuroToxicology! Here, we studied the effects of exposure to two widely used insecticides, chlorpyrifos and diazinon, and their -oxon metabolites. Our results show that these compounds can affect neuronal activity…

We are pleased to tell you that a shared paper from our group, titled ‘Culture of Rat Primary Cortical Cells for Microelectrode Array Recordings to Screen for Acute and Developmental Neurotoxicity’ has been published in Current Protocols in Toxicology! In this paper we provide a detailed protocol on the main method we use in the Neurotoxicology…