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Inhibitory effects of (synthetic) cannabinoids and (designer) benzodiazepines on spontaneously active neuronal networks of primary rat cortical cultures in vitro
The use of novel psychoactive substances (NPS), often sold as so-called “designer drugs,” has risen sharply over the past two decades and is increasingly linked to serious health incidents. In our latest study, we investigated how a range of commonly used and emerging psychoactive drugs affect neuronal activity using rat primary cortical cells cultured on…
Read moreThe plastic brain part II: new insights into micro- and nanoplastics neurotoxicity.
We are pleased to announce the publication of our latest review article, “The plastic brain part II: new insights into micro- and nanoplastics neurotoxicity”, in the journal Microplastics and Nanoplastics. Micro- and nanoplastics are ubiquitous in the environment, and because human exposure is unavoidable, there is growing interest in understanding their potential impacts on the nervous…
Read moreDose-response assessment of neuroactive botanical extracts and their bioactive constituents using microelectrode array (MEA) recordings in rat primary cortical cultures
Our work in collaboration with the HESI Botanical Safety Consortium was recently published in Pharmaceutical Biology! The HESI Botanical Safety Consortium collaborates to develop screening strategies to efficiently identify botanical-induced toxicity. Our study aimed at establishing the neuroactive potential of 13 botanical extracts using microelectrode array (MEA) recordings in rat primary cortical cultures.Our results show…
Read moreA Review of Toxicological and Exposure Data on Polymeric Antioxidant By-products
Our latest review on antioxidant by-products (ABPs) has been published in Reviews of Environmental Contamination and Toxicology! This work summarizes the current state of toxicological, ecotoxicological, exposure, and mechanistic data on ABPs—also known as Arvin substances, which are degradation products of antioxidants formed under heat or pressure. Toxicological data were identified for ABP 1 (4-ethylphenol),…
Read moreAcute, prolonged, and chronic exposure to organochlorine insecticides evoke differential effects on in vitro neuronal activity and network development
Our latest study from the ENDpoiNTs project has been published in NeuroToxicology! In this study, we examined the effects of acute (30 minutes), prolonged (up to 48 h), and chronic (21 days) exposure to DDT, its metabolite DDE, endosulfan, dieldrin, and lindane on neuronal activity and network development in sex-separated rat primary cortical cultures using micro-electrode array…
Read moreThe effects of acute and chronic exposure to bisphenols and PFAS on neuronal activity and network development
In our latest study, we investigated the neurotoxic effects of acute and chronic exposure to bisphenols and perfluoroalkyl substances (PFAS) on neuronal activity and network development. Specifically, we assessed the effects of bisphenol-A (BPA), bisphenol-F (BPF), bisphenol-S (BPS), perfluorooctanoate (PFOA), perfluorooctanesulfonate (PFOS), and perfluorohexanesulfonate (PFHxS) in rat primary cortical cultures using micro-electrode array recordings. Our…
Read moreExposure to organophosphate flame retardants and phthalates alters neuronal activity and network development
In our latest article, we studied the neurotoxic effects of acute and chronic exposure to organophosphate flame retardants (OPFRs) and phthalates on neuronal activity and network development. Specifically, we studied the effects of triphenyl phosphate (TPhP), diethyl phthalate (DEP), dibutyl phthalate (DBP), benzyl butyl phthalate (BBzP), bis(2-ethylhexyl) phthalate (DEHP), and their metabolites using micro-electrode array…
Read moreComparison of the neurotoxic potency of different ultrafine particle fractions from diesel engine exhaust following direct and simulated inhalation exposure
In our recent study, we investigated the neurotoxicity of ultrafine particles (< 100 nm; UFP) emitted from diesel engines, comparing different fuel types and particle fractions. Specifically, we studied the effect of solid and semi-volatile organic compound (SVOC) UFP derived from petroleum diesel and Hydrotreated Vegetable Oil-type fuel on neuronal function after direct exposure and…
Read moreEffects of chronic insecticide exposure on neuronal network development in vitro in rat cortical cultures
In this article, we present sex-specific in vitro data on the chronic neurotoxic effects of different classes of insecticides. Specifically, we studied the sex-specific effects of different carbamates, organophosphates, and pyrethroids on neuronal network development in sex-separated primary rat cortical cultures using micro-electrode array (MEA) recordings. Our findings indicate that exposure for 1 week to…
Read moreEffects of acute insecticide exposure on neuronal activity in vitro in rat cortical cultures
In our recent article, we present sex-specific in vitro data on the acute neurotoxicity of different classes of insecticides. Specifically, we studied the sex-specific effects of different carbamates, organophosphates, organochlorines, and pyrethroids on neuronal network function in sex-separated rat primary cortical cultures using micro-electrode array (MEA) recordings. Our findings indicate that exposure to the organophosphates…
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