Our latest review on antioxidant by-products (ABPs) has been published in Reviews of Environmental Contamination and Toxicology! This work summarizes the current state of toxicological, ecotoxicological, exposure, and mechanistic data on ABPs—also known as Arvin substances, which are degradation products of antioxidants formed under heat or pressure. Toxicological data were identified for ABP 1 (4-ethylphenol),…

Our latest study from the ENDpoiNTs project has been published in NeuroToxicology! In this study, we examined the effects of acute (30 minutes), prolonged (up to 48 h), and chronic (21 days) exposure to DDT, its metabolite DDE, endosulfan, dieldrin, and lindane on neuronal activity and network development in sex-separated rat primary cortical cultures using micro-electrode array…

In our latest study, we investigated the neurotoxic effects of acute and chronic exposure to bisphenols and perfluoroalkyl substances (PFAS) on neuronal activity and network development. Specifically, we assessed the effects of bisphenol-A (BPA), bisphenol-F (BPF), bisphenol-S (BPS), perfluorooctanoate (PFOA), perfluorooctanesulfonate (PFOS), and perfluorohexanesulfonate (PFHxS) in rat primary cortical cultures using micro-electrode array recordings. Our…

In our latest article, we studied the neurotoxic effects of acute and chronic exposure to organophosphate flame retardants (OPFRs) and phthalates on neuronal activity and network development. Specifically, we studied the effects of triphenyl phosphate (TPhP), diethyl phthalate (DEP), dibutyl phthalate (DBP), benzyl butyl phthalate (BBzP), bis(2-ethylhexyl) phthalate (DEHP), and their metabolites using micro-electrode array…

In our recent study, we investigated the neurotoxicity of ultrafine particles (< 100 nm; UFP) emitted from diesel engines, comparing different fuel types and particle fractions. Specifically, we studied the effect of solid and semi-volatile organic compound (SVOC) UFP derived from petroleum diesel and Hydrotreated Vegetable Oil-type fuel on neuronal function after direct exposure and…

In this article, we present sex-specific in vitro data on the chronic neurotoxic effects of different classes of insecticides. Specifically, we studied the sex-specific effects of different carbamates, organophosphates, and pyrethroids on neuronal network development in sex-separated primary rat cortical cultures using micro-electrode array (MEA) recordings. Our findings indicate that exposure for 1 week to…

In our recent article, we present sex-specific in vitro data on the acute neurotoxicity of different classes of insecticides. Specifically, we studied the sex-specific effects of different carbamates, organophosphates, organochlorines, and pyrethroids on neuronal network function in sex-separated rat primary cortical cultures using micro-electrode array (MEA) recordings. Our findings indicate that exposure to the organophosphates…

In our recent article, we present in vitro data on the neurotoxicity of combustion-derived particulate matter (PM). Specifically, we studied and compared the effects and potency of PM generated using diesel and biodiesel fuel on neuronal function. Moreover, we applied a novel approach to investigate the indirect effects of particles on neuronal function and health…

Our work in collaboration with the HESI Botanical Safety Consortium was recently published! The HESI Botanical Safety Consortium collaborates to develop screening strategies to efficiently identify botanical-induced toxicity. We presented in vitro data that evaluates the applicability of multi-well microelectrode array (MEA) recordings for screening and prioritizing botanical extracts for their neuroactive potential. Most botanical…

Plastics zijn overal. In de bodem, de lucht, water en voedsel. Plastic valt uit elkaar in kleine en nog kleinere deeltjes – micro- en nanoplastics – die we met het blote oog niet kunnen zien. Ze komen terecht in onze organen en ons bloed. Hoe schadelijk is dat? Een gesprek met drie experts. Lees het…